细胞间黏附分子-1(ICAM-1)分布于体内多种组织细胞表面,是具有广泛生物学活性的一种黏附因子,在炎症与免疫应答、信号转导、组织修复等多种生理与病理过程中起重要作用。现就ICAM-1在体内的表达与调控,以及其在某些中枢神经系统疾病发病中的作用作一综述。 Intercellular adhesion molecule-1 (ICAM-1) is distributed on the surface of many tissue cells in vivo and is a kind of adhesion factor with a wide range of biological activities. ICAM-1 is widely used in many physiological and pathological processes such as inflammation and immune response, signal transduction and tissue repair Play an important role in the process. Now on the expression and regulation of ICAM-1 in vivo and its role in the pathogenesis of some diseases of the central nervous system are reviewed.