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本文对我国戊型肝炎的流行病学、病原学、动物实验感染、临床、组织病理学及预防进行了研究。戊型肝炎主要侵犯青壮年;儿童和老人发病较少;男性多于女性;主要经污染的水和食物传播。从戊型肝炎病人和实验感染HEV猕猴粪便中检测到HEV并获得HEV cDNA克隆。中国和缅甸株HEV核甙酸和氨基酸的同源性分别为94.3％和99.6％。对562例戊型肝炎病人的临床特点和7例黄疸型成型肝炎病人的肝活检组织病理学改变进行了分析。随机双盲对照试验证明,血清免疫球蛋白对控制戊型肝炎无效。
In this paper, the epidemiology, etiology, animal experimental infection, clinical, histopathology and prevention of hepatitis E in China were studied. Hepatitis E mainly affects young adults; children and the elderly have fewer illnesses; men are more likely than women; and mainly polluted water and food are transmitted. HEV was detected from Hepatitis E patients and experimentally infected HEV macaques and HEV cDNA clones were obtained. The nucleotide and amino acid homology of HEV in China and Myanmar were 94.3% and 99.6% respectively. The clinical features of 562 patients with hepatitis E and the histopathological changes of hepatic biopsy in 7 patients with jaundice-type hepatitis were analyzed. Randomized double-blind controlled trials have shown that serum immunoglobulins are ineffective in controlling hepatitis E.