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类风湿性关节炎是一种临床难治的顽症。临床上我们用威灵通痹冲剂治疗类风湿性关节炎,取得了一定的效果。为了进一步探讨其作用机理,进行了该药的药效学研究,结果报告如下。 材料与方法 1.材料 1.1 药物:威灵通痹冲剂由威灵仙、豨莶草、透骨草、穿山龙、细辛、川牛膝、甘草等组成。吲哚美辛片,河南泌阳制药厂生产,批号940822,芬必得,中美史克制药有限公司产品;牛Ⅱ型胶原,美国sigma公司产品。 1.2 动物:SD大白鼠、雌雄各半;体重150±10g;昆明种小白鼠,雌雄各半,体重18-23g,均由河南医科大学实验动物中心提供。 方法 1 大鼠关节炎试验:用乙醚麻醉大鼠,以牛Ⅱ型胶原加福氏完全佐剂注射于左足垫内即可。造模动
Rheumatoid arthritis is a chronic refractory disease. Clinically, we Weide Tongbi granules treatment of rheumatoid arthritis, and achieved some results. In order to further explore its mechanism of action, conducted a pharmacodynamic study of the drug, the results reported below. Materials and Methods 1. Materials 1.1 Drugs: Weiling Tongbi granules from Clematis, Aesculapis, Speranskia grass, dragon, Asarum, Achyranthes, licorice and other components. Indomethacin tablets, Henan Biyang Pharmaceutical Factory production, batch number 940822, Fenbid, Sino-US Shi Ke Pharmaceutical Co., Ltd. products; cattle Ⅱ collagen, the United States sigma company’s products. 1.2 Animals: SD rats, male and female; weight 150 ± 10g; Kunming mice, male and female, weight 18-23g, provided by the Experimental Animal Center of Henan Medical University. Method 1 Rat arthritis test: Rats were anesthetized with ether and injected with complete adjuvant with bovine type Ⅱ collagen plus Freunds in the left foot pad. Modeling move