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纸喷雾质谱法是一种新型的敞开式质谱技术,其以低价易处理的纸为载体,将样品加在三角形的纸上,通过施加高电压,目标分子在电场的驱动下到达纸尖,瞬间气化形成电喷雾,样品离子化后进入质谱进行分析。它具有敞开式质谱法和电喷雾电离技术的特点,可以在开放式大气压环境下对样品或样品表面的物质进行分析,分析成本低、高通量、简便、实时、快速,可简化工作流程,提高质谱仪器的易用性。本文从纸喷雾质谱法的原理出发,介绍了影响其电离效率的主要因素(如载体基质,溶剂系统,洗脱方式等),并对近几年该技术的改进和发展,及其在生物样品检测、植物化学分析、品种鉴别、食品安全和环境分析等领域的应用进行了综述,全面介绍了该项技术的特点和优势。多项研究证明纸喷雾质谱法是一个应用面广泛,具有很大发展前景的分析技术,对其开展研究工作十分有意义。最后讨论了纸喷雾质谱法存在的不足,并提出了相关改进的设想。
Paper Spray Mass Spectrometry is a new open mass spectrometry technique that uses low-cost, easy-to-process paper as the carrier. The sample is applied to a triangular paper. By applying a high voltage, the target molecule reaches the tip of the paper driven by the electric field. Gasification instantly formed electrospray, sample ionization into the mass spectrometry analysis. It has the advantages of open mass spectrometry and electrospray ionization technology. It can analyze the sample or sample surface under open atmospheric pressure environment. It has the advantages of low cost, high throughput, simple, real-time and fast, which can simplify the workflow, Improve the ease of use of mass spectrometry instruments. Based on the principle of paper spray mass spectrometry, the main factors affecting the ionization efficiency (such as carrier matrix, solvent system and elution method) are introduced. The improvement and development of the technology in recent years and its application in biological samples Detection, phytochemical analysis, variety identification, food safety and environmental analysis areas such as the application are reviewed, a comprehensive description of the characteristics of the technology and advantages. Several studies have proved that paper spray mass spectrometry is a wide range of applications, with great prospects for the development of analytical techniques, its research work is very meaningful. Finally, the paper discusses the shortcomings of paper spray mass spectrometry, and puts forward the ideas of related improvements.