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目的探讨安吉县HIV/AIDS免费抗病毒治疗效果及影响因素。方法从“中国疾病预防控制信息系统”“艾滋病抗病毒治疗数据管理系统”导出安吉县高效抗逆转录病毒治疗(HAART)的HIV/AIDS 53例病例资料,比较治疗前后CD4+T淋巴细胞数,并分析影响治疗效果的因素。结果抗病毒治疗前、治疗6个月和治疗12个月后HIV/AIDS的CD4+T淋巴细胞数分别为(239.4±138.4)、(348.2±168.6)和(372.9±184.1)个/μL,差异有统计学意义(P<0.01)。Logistic回归分析显示,HIV/AIDS年龄≥40岁治疗效果是<40岁的4.88倍,基线CD4+T淋巴细胞计数≥200个/μL组是<200个/μL组的6.10倍。结论经免费抗病毒治疗后,HIV/AIDS免疫重建效果明显;抗病毒治疗时年龄≥40岁和基线CD4+T淋巴细胞计数≥200个/μL者治疗效果较好。
Objective To investigate the effect and influencing factors of free antiviral treatment of HIV / AIDS in Anji County. Methods The data of 53 cases of HIV / AIDS from Anji County Highly Effective Anti-retroviral Therapy (HAART) were derived from the “China Disease Prevention and Control Information System” “HIV / AIDS Treatment Data Management System ”. The levels of CD4 + T Lymphocytes, and analyze the factors that affect the therapeutic effect. Results The number of CD4 + T lymphocytes of HIV / AIDS patients before treatment with antiviral therapy for 6 months and 12 months after treatment was (239.4 ± 138.4), (348.2 ± 168.6) and (372.9 ± 184.1) / μL, respectively There was statistical significance (P <0.01). Logistic regression analysis showed that the treatment effect of HIV / AIDS patients ≥40 years old was 4.88 times that of <40 years old, and the baseline CD4 + T lymphocyte count ≥200 cells / μL group was 6.10 times that of <200 cells / μL group. Conclusion The results of immune reconstruction of HIV / AIDS are obvious after free antiviral therapy. The effect of anti-virus treatment is better than 40 years old and baseline CD4 + T lymphocyte count ≥200 / μL.