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以二硝基氯苯法制作大鼠溃疡性结肠炎模型，埋藏电极记录结肠电，并以标准对照比色法测定结肠组织浸泡液中ＮＯ代谢产物亚硝酸盐（ＮＯＰ）的浓度，观察中药复方“胃肠康”的作用。发现溃疡性结肠炎大鼠结肠的亚硝酸盐浓度显著高于正常，结肠基本电节律（ＢＥＲ）幅值及收缩性复合肌电（ＣＥＣ）幅值均显著降低，负载峰电的ＢＥＲ和ＣＥＣ百分数明显减少。经中药治疗后，模型动物结肠的病理改变明显减轻，结肠电倾向恢复正常，同时ＮＯＰ亦回降至正常水平。结果提示，ＮＯ在溃疡性结肠炎的病理过程及结肠电改变中具有重要的作用，中药复方“胃肠康”的作用机制与调整ＮＯ密切相关。
The model of ulcerative colitis was established by dinitrochlorobenzene method. The colorectal electric potential was recorded by the buried electrode. The NO metabolite nitrite (NOP) concentration in the soaking solution of colonic tissue was measured by standard contrast colorimetry. “Gastrointestinal health” role. It was found that the nitrites concentrations in the colon of ulcerative colitis rats were significantly higher than those in normal rats. The values of basic electrical activity (rms) amplitude and contractile composite electromyography (CEC) amplitude were significantly decreased. The percentages of BER and CEC obviously decrease. After the treatment of traditional Chinese medicine, the model animal colon pathological changes significantly reduced, the tendency to return to normal colonic, NOP also back to normal levels. The results suggest that NO plays an important role in the pathological process of ulcerative colitis and the changes of colonic electricity. The mechanism of action of traditional Chinese medicine “WEIJANG” is closely related to the regulation of NO.