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目的 观察致敏豚鼠接种卡介苗后临床反应及病理变化。方法 冻干BCG接种经BCG致敏的和未经BCG致敏的正常豚鼠 ,观察接种后的反应及肝、脾、肺和肠系膜淋巴结的病理变化。结果 未致敏豚鼠局部未出现迟发型变态反应及全身反应 ,致敏豚鼠局部出现迟发型变态反应及坏死 ;两组豚鼠接种后均出现上皮样细胞肉芽肿病理改变。结论 两组豚鼠接种后虽临床反应不同 ,但病理改变无差异
Objective To observe the clinical response and pathological changes of sensitized guinea pigs after inoculation of BCG. Methods Lyophilized BCG was used to inoculate normal guinea pigs which were sensitized by BCG and not sensitized by BCG. The pathological changes of the liver, spleen, lung and mesenteric lymph nodes were observed after inoculation. Results Delayed type hypersensitivity reaction and systemic reaction were not observed in the non-sensitized guinea pigs. Delayed type hypersensitivity reaction and necrosis occurred in the sensitized guinea pigs. Pathological changes of epithelioid granulomatous cells occurred in both guinea pigs. Conclusion Although the clinical response of guinea pigs after vaccination is different, the pathological changes are not different