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随着分子生物学技术的提高,针对细胞受体和调控分子为靶点的靶向治疗已成为国内外肿瘤治疗的热点。表皮生长因子受体(EGFR)与多种实体肿瘤的发生、发展及肿瘤的侵袭、转移有密不可分的关系,如在卵巢癌、肺癌、头颈部癌等肿瘤中,都检测到EGFR的高表达。表皮生长因子及其阻滞剂的研究在临床肿瘤的治疗中显示出了巨大的潜力。EGFR在肾癌细胞中高表达,本文就针对近年EGFR在肾癌中的研究进展作一综述。
With the improvement of molecular biology techniques, targeted therapy targeting cell receptors and regulatory molecules has become a hot spot in cancer treatment at home and abroad. Epidermal growth factor receptor (EGFR) and a variety of solid tumor occurrence and development and tumor invasion and metastasis are inextricably linked, such as ovarian cancer, lung cancer, head and neck cancer and other tumors were detected EGFR high expression. Epidermal growth factor and its blockers have shown great potential in the treatment of clinical tumors. EGFR is highly expressed in renal cell carcinoma, this article reviews the research progress of EGFR in renal cell carcinoma in recent years.