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TRAIL是新的肿瘤坏死因子 (tumor necrosis factor,TNF)家族成员 ,对大多数的肿瘤细胞有很强的杀伤作用 ,它能介导病毒引起的凋亡 ,在一些自身免疫病中也起作用。本文对 TRAIL的结构和功能以及它的较为复杂的受体系统、配体 -受体系统介导的细胞凋亡、TRAIL在病毒引起的细胞凋亡中的作用方面做了较为详尽的综述。
TRAIL is a new family member of the tumor necrosis factor (TNF) family and has a potent killer effect on most tumor cells. It mediates virus-induced apoptosis and also plays a role in some autoimmune diseases. In this review, the structure and function of TRAIL as well as its more complex receptor system, ligand-receptor system-mediated apoptosis, and TRAIL’s role in virus-induced apoptosis are reviewed in detail.