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目的观察6种常用的调理脾胃方药补中益气汤、大承气汤、归脾汤、温胆汤、瓜蒂散、草果知母汤对脑内单胺类神经递质,包括去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)以及代谢产物5-羟吲哚乙酸(5HIAA)、高香草酸(HVA)含量的变化。方法分别给予大鼠6种中药汤剂灌胃,15d后,采用高效液相-电化学法检测大鼠脑内单胺类递质的含量。结果补中益气汤、归脾汤可增加脑组织NE的含量,大承气汤有降低皮层和海马NE的作用,草果知母汤可降低海马DA的含量,温胆汤则可降低皮层DA的含量,瓜蒂散可升高皮层NE含量。结论不同的调理脾胃方药作用于单胺类递质的部位和趋势有所不同:温补和吐泻的调理脾胃药以作用于NE系统为主,调畅气机的脾胃药以作用于DA系统为主。
Objective To observe the effects of six kinds of commonly used spleen-and-stomach tonics: Buzhong Yiqi Decoction, Dachengqi Decoction, Guipi Decoction, Wendan Decoction, Guadi San, and Caoguo Zhimu Decoction on brain monoamine neurotransmitters, including deprotection Changes in levels of epinephrine (NE), dopamine (DA), serotonin (5-HT), and metabolites of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA). Methods Rats were given intragastric administration of 6 kinds of traditional Chinese medicine decoction respectively. After 15 days, the content of monoamine neurotransmitters in rat brain was determined by high performance liquid-electrochemical method. Results Buzhong Yiqi Decoction and Guipi Decoction can increase the content of NE in brain tissue. Dachengqi Decoction can reduce the effect of cortex and hippocampus NE. Caoguo Zhimu Decoction can reduce the content of DA in hippocampus, while Wendan Decoction can reduce the cortex. The content of DA, Guati San can increase the content of NE in the cortex. Conclusions The position and tendency of different conditioning spleen-stomach prescriptions acting on monoamine transmitters are different: warming and vomiting and diarrhea modulate the spleen and stomach medicine to act on the NE system, and adjust the qi machine’s spleen and stomach medicine to act on the DA system. the Lord.