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目的··:探讨5 -HT2A 受体基因多态性与海洛因依赖易感性的关系。方法··:用聚合酶链式反应 (PCR)技术结合限制性片段长度多态性 (RFLP)分析技术 ,检测了99名海洛因依赖者和80名正常对照者5 -HT2A 受体基因1438A/G多态性的基因型和等位基因频率。结果··:海洛因依赖者5 -HT2A 受体基因1438A/G多态性基因型A1/A2的频率较对照组高。结论··:5 -HT2A 受体基因1438A/G多态性可能与海洛因依赖的易感性有关
Objective: To investigate the relationship between 5-HT2A receptor gene polymorphism and susceptibility to heroin addicts. Methods · · ·: Polymerase chain reaction (PCR) combined with restriction fragment length polymorphism (RFLP) analysis of 99 heroin dependent and 80 normal controls 5-HT2A receptor gene 1438A / G Polymorphism genotypes and allele frequencies. Results · · ·: The herpes addicts 5-HT2A receptor gene 1438A / G polymorphism genotype A1 / A2 frequency higher than the control group. CONCLUSIONS: The 5-HT2A receptor gene 1438A / G polymorphism may be related to heroin dependence