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耐碳青霉烯类铜绿假单胞菌(carbapenem-resistant Pseudomonas aeruginosa,CRPA)已有在医院院内爆发流行的趋势,治疗失败率和病死率高,有效的单用抗菌药物非常有限,往往建议联合用药治疗CRPA感染。笔者就联合用药治疗CRPA感染的体内外效应及临床研究方面进行综述,以全面掌握联合用药治疗CRPA感染的研究进展,为临床合理使用联合方案治疗CRPA感染提供一定的试验基础。
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) has been prevalent in hospitals and has a trend toward high rates of treatment failure and mortality with effective antimicrobials being very limited Medication for CRPA infection. The author summarizes the in vitro and in vivo effects and clinical studies of combination therapy on CRPA infection in order to fully grasp the research progress of combination therapy in the treatment of CRPA infection and provide experimental basis for clinical rational use of combination regimen in the treatment of CRPA infection.