In this paper, a novel copper-based catalyst for FCC gasoline improving the ability of removal the sulfur and avoiding the loss of the octane number from olefin saturation by reactive adsorption desulfuriza- tion (RADS) was investigated. The series of Cu/ZnO-Al2O3 catalysts were characterized by X-ray powder diffraction (XRD), N 2 adsorption analysis and temperature-programmed reduction (TPR) studies, X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM) and transmission electron mi- croscopy (TEM). The experiment results showed that the catalysts had an optimum desulfurization ability with copper loading 6 wt％, which the sulfur contents of product decreased less than 10 μg/g and olefin contents decreased from 16.19％ to 14.14％ for the long period operation. The appropriate Cu loading con- tent could lead to the high active and low apparent activation energy ( E a ). Therefore, the Cu-based cat- alyst may become a novel catalyst for second-generation for reactive adsorption desulfurization, which achieves the high desulfurization active and low olefins saturation to satisfy the upgrading the product.