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目的研究小肠电刺激对人小肠传输功能的影响。方法健康正常人12名,经胃镜于十二指肠内植入带有环状电极的鼻胃管,经胃管注入混合有~(99)Tc~m的不吸收的电解质平衡液,检测给予真性或假性小肠电刺激后核素到达回盲部时间,同时对受检者在实验中发生的消化不良症状严重程度进行评分。结果 (1)真性小肠电刺激时核素到达回盲部时间为(28±10)min,显著低于假性小肠电刺激组[(39±17)min,P<0.05]。(2)给予真性刺激前后志愿者自觉症状评分间差异无统计学意义(中位数为1.0 vs 1.5,P>0.05),真性刺激与假性刺激(自觉症状评分中位数为0.5)间差异也无统计学意义(P>0.05)。结论小肠电刺激可加速人体小肠传输,且不引起消化不良症状,叮能成为治疗小肠动力障碍性疾病的新方法。
Objective To study the effect of small intestine electrical stimulation on human intestinal transit function. Methods Twelve healthy subjects were enrolled into the duodenum by gastroscope. The nasogastric tube with ring electrodes was implanted into the duodenum by gastroscope. The non-absorbed electrolyte balance solution mixed with ~ (99) Tc ~ The nuclide reached the ileocecal time after the true or pseudo-small intestine electrical stimulation, and scored the severity of the dyspeptic symptom in the experiment. Results (1) The time of nuclide reaching the ileocecal junction was (28 ± 10) min, which was significantly lower than that of the pseudo-small intestine electrical stimulation group [(39 ± 17) min, P <0.05]. (2) There was no significant difference in volunteer symptom score before and after the stimulation (median 1.0 vs 1.5, P> 0.05), the difference between true and false stimulation (median of symptom score 0.5) Nor statistically significant (P> 0.05). Conclusion Small intestine electrical stimulation can accelerate the intestinal transit in the human body without causing dyspeptic symptoms and can become a new method for the treatment of small bowel motility disorder.