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儿童缺乏维生素A有使发病率和死亡率增加的危险。在一个地方性流行性维生素A缺乏地区进行了补充维生素A试验,大多数补充试验都显著地降低了儿童死亡率。而本次试验是在尼泊尔的一个农村进行的。该村地处南亚恒河涝源地区,具有一定代表性。 28630名学龄前儿童,年龄6个月～5岁,随机分成2组,采用双盲方法进行试验。一组每4个月补充维生素A胶囊[6000视黄醇当量],对照组给予安慰剂胶囊(含维生素A为300视黄醇当量)。 12个月后停止试验,发现与对照组相比补充维生素A组的相对死亡危险度为0.70(95％可信限为
Lack of vitamin A in children is at increased risk of morbidity and mortality. Vitamin A supplementation was performed in a endemic area of vitamin A deficiency and most of the supplemental trials significantly reduced child mortality. This test was conducted in a rural area of Nepal. The village is located in South Asia Ganges waterlogging area, has a certain representation. 28630 pre-school children, aged 6 months to 5 years, were randomized into two groups and tested in a double-blind manner. One group received vitamin A capsules [6000 retinoid equivalents] every 4 months and a placebo capsule (containing 300 retinoid equivalents of vitamin A) in the control group. After 12 months, the trial was stopped and the relative risk of death from the vitamin A supplementation group was found to be 0.70 (95% confidence limit