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某些钙内流阻滞剂能影响地高辛的药代学过程,因而应考虑调整地高辛的剂量。本文研究心痛定对血清地高辛浓度的影响。 14例心脏病人,男10例,女4例;年龄49～75(平均64.1±8.4)岁。地高辛维持量为0.25mg/d(13例),0.375mg/d(1例)。其中13例为冠心病,1例为高血压。合用心痛定剂量为30～60mg/d,用放射免疫法测定服用心痛定前后血清地高辛浓度,并作统计学处理。结果 8例在住院期间测定,用心痛定前地高辛平均浓度为0.92±0.5ng/ml,用药4天后浓度为
Some calcium blockers can affect the digoxin pharmacokinetic process, and therefore should consider adjusting the dose of digoxin. This article studies the effect of nifedipine on serum digoxin concentrations. 14 cases of heart disease, 10 males and 4 females; aged 49 to 75 (average 64.1 ± 8.4) years. Digoxin maintenance 0.25mg / d (13 cases), 0.375mg / d (1 case). Of these, 13 were coronary heart disease and 1 was hypertension. Combination of nifedipine given dose of 30 ~ 60mg / d, radioimmunoassay determination of taking heartache given serum digoxin concentration, and for statistical analysis. Results Eight patients were determined during hospitalization. The mean digoxin concentration was 0.92 ± 0.5 ng / ml before and after 4 days of treatment. The concentration of digoxin was