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ＨＢＶＤＮＡ基因经聚合酶链反应 (ＰＣＲ )、分子克隆及序列分析等检测手段可发现其突变 ,以前核心区尤为显著。我院与复旦大学医学院附属中山医院 ,复旦大学遗传学研究所于 1999年 3月对 1996年 6月～ 1997年 10月收集的 5 9例慢性乙型肝炎的标本作前Ｃ区基因分析研究 ,现报
HBVDNA gene by polymerase chain reaction (PCR), molecular cloning and sequence analysis and other detection means can be found in the mutation, especially in the former core area. Our hospital and Fudan University School of Medicine Zhongshan Hospital, Fudan University Institute of Genetics in March 1999 on June 1996 ~ October 1997 collection of 59 samples of chronic hepatitis B pre-C gene analysis Now reported