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目的探讨新生儿低血糖性脑病患儿神经系统的发育情况,为临床诊断、治疗提供参考。方法 120例新生儿低血糖性脑病患儿作为低血糖性脑病组,同期100例正常分娩新生儿为对照组,比较两组神经行为测定(NBNA)评分,并采用阿米尔-梯桑(Amiel-Tison)法对患儿神经系统发育进行监测。比较两组血清胰岛素样生长因子及白细胞介素2、白细胞介素6及S100B蛋白水平。结果低血糖性脑病组三个测查时间(3~7、12~14、24~26 d)的NBNA评分均低于对照组,差异有统计学意义(P<0.05)。低血糖性脑病组患儿血清胰岛素样生长因子及白细胞介素2、白细胞介素6及S100B蛋白水平均明显高于对照组,差异有统计学意义(t=19.929、14.081、14.933、17.291,P<0.05)。结论新生儿低血糖性脑病患儿存在明显的神经系统发育障碍,胰岛素样生长因子与白细胞介素也与新生儿低血糖性脑病患儿神经系统发育异常相关。
Objective To investigate the development of nervous system in children with hypoglycemic encephalopathy and provide reference for clinical diagnosis and treatment. Methods A total of 120 neonates with hypoglycemic encephalopathy (Hypoglycemic encephalopathy) were enrolled in this study. One hundred newborns with normal birth were enrolled in this study. The NBNA score was compared between two groups. Amiel- Tison) method to monitor children’s nervous system development. Serum insulin-like growth factor and interleukin 2, interleukin 6 and S100B protein levels were compared between the two groups. Results The NBNA scores of hypoglycemic encephalopathy group were lower than those of control group in three test periods (3 ~ 7,12 ~ 14,24 ~ 26 d), the difference was statistically significant (P <0.05). The levels of serum insulin-like growth factor and interleukin-2, interleukin-6 and S100B in children with hypoglycemic encephalopathy were significantly higher than those in the control group (t = 19.929,14.081,14.933,17.291, P <0.05). Conclusion There are obvious neurodevelopmental disorders in neonates with hypoglycemic encephalopathy. Insulin-like growth factor and interleukin are also associated with abnormal neuronal development in children with hypoglycemic encephalopathy.