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环境改变和污染所引起下一代的变化是深刻的,其中胎儿则是最敏感的人群之一。持续性有机污染物(POPs)是环境中很重要的一类化学污染物,随着气候变化和经济快速发展使得其暴露水平和模式也发生改变~([1])。虽然许多POPs在多年前已被淘汰,但由于它们具有持久性、亲脂性、生物累积性、半挥发性和高毒性,在环境中仍有残留。目前国内外动物实验和人群流行病学调查研究显示,孕期暴露POPs可能会对妊娠结局及儿童生长发育产生不良影响。其中包括低出生体质量、早产、出生缺陷、儿童神经系统和生殖系统发育不良等,本文以人群流行病调查资料为基础对孕期暴露POPs对下一代产生的上述影响进行阐述。
Changes in the environment and pollution caused by the next generation of changes is profound, of which the fetus is one of the most sensitive groups. Persistent organic pollutants (POPs) are very important chemical pollutants in the environment, and their exposure levels and modes also change with the rapid development of climate and economy ([1]). Although many POPs have been phased out many years ago, they remain in the environment due to their persistence, lipophilicity, bioaccumulation, semi-volatility and high toxicity. At present, domestic and foreign animal experiments and population epidemiological studies show that exposure to POPs during pregnancy may have adverse effects on pregnancy outcomes and children’s growth and development. These include low birth weight, premature birth, birth defects, childhood nervous system and reproductive system dysplasia. Based on the population epidemiological survey data, this article describes the above effects of exposure to POPs during pregnancy on the next generation.