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慢性维生素A过多症的临床表现是多种多样的。最常见的是脱屑、落发、无力、食欲不振、恶心、呕吐、肌肉骨骼疼痛、头痛和脾大。伴有高血钙症者,文献中仅有4例报告。本文报告1例17岁男性,1年前因患痤疮开始服维生素A每日15万单位。最初感倦怠,入院前3周反复发生鼻衄,随即出现食欲不振、恶心、呕吐、便秘、前额痛、眩晕、夜尿、下背痛、肩胛骨下方和右侧三角肌区域疼痛和头发脱落。此时自动停止服药。体检发现肝脾肿大约1厘米,嘴唇皮肤皲裂,掌跖皮肤明显剥脱,全部甲的近端均有白线。实验室检查发现凝血酶原指数67%,尿素11.45毫克分子/升,肌酸酐114.9微克分子/升,钙3毫克分
The clinical manifestations of chronic vitamin A hyperactivity are varied. The most common are scaling, hair loss, weakness, loss of appetite, nausea, vomiting, musculoskeletal pain, headache and splenomegaly. Accompanied by hypercalcemia, only 4 cases reported in the literature. This article reports a 17-year-old man who started taking vitamin A 150,000 daily a year ago because of acne. The initial feeling of fatigue, 3 weeks before admission, recurrent epistaxis, followed by loss of appetite, nausea, vomiting, constipation, forehead pain, dizziness, nocturia, lower back pain, scapula below and right deltoid area pain and hair loss. At this point automatically stop taking medicine. Physical examination found that about 1 cm hepatosplenomegaly, lip chapped skin, palmoplantar skin was exfoliative, all the proximal white line. Laboratory tests revealed a 67% prothrombin index, 11.45 milliliters of urea / liter, 114.9 micrograms of creatinine per liter, 3 milligrams of calcium