端粒、端粒酶是近来生命科学和肿瘤学研究的热点。研究表明，端粒、端粒酶的变化，包括端粒序列、行为异常及端粒酶的异常激活等与肿瘤的发生发展有着重要关系，并可能因此而提供一条肿瘤广谱治疗的新途径。本文着重综述端粒和瑞粒酶在消化道肿瘤方面的相关研究近展。 Telomeres and telomerase are hot spots in recent life sciences and oncology research. Studies have shown that changes in telomeres and telomerase, including telomere sequences, abnormal behaviors, and abnormal activation of telomerase, have an important relationship with the occurrence and development of tumors, and may thus provide a new approach for broad-spectrum treatment of tumors. This article focuses on the recent research on the related research of telomere and ribozyme in digestive tract tumors.