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目的:了解沈阳市0～9岁儿童微量元素(铁、锌、镁、铜)水平，并探讨微量元素与免疫球蛋白(IgA、IgG、IgM)的关系。方法:对2018年9月至2019年10月在中国医科大学附属第四医院就诊并行微量元素及血清免疫球蛋白检测的0～9岁儿童422例的临床资料进行回顾性分析。结果:共有422名儿童符合标准，其中男童228名和女童194名。0～3岁、>3～6岁、>6～9岁儿童铁缺乏率分别为17.5%、18.2%、14.0%，差异无统计学意义(χn 2＝0.520，n P>0.05)，锌缺乏率分别10.0%、9.0%、10.5%，差异亦无统计学意义(χn 2＝0.135，n P>0.05)，所有儿童镁、铜水平均在正常范围。锌缺乏组IgA、IgG分别为(1.24±0.77)g/L、(9.07±3.04)g/L，明显低于锌正常组的(0.94±0.55)g/L、(8.18±2.11)g/L，差异均有统计学意义(n t＝-2.858、-2.440，均n P0.05)。铁缺乏组与铁正常组间IgA、IgG、IgM水平差异均无统计学意义(n t＝-1.346、-0.960、0.029，均n P>0.05)。锌水平与IgA、IgG水平之间存在明显正相关(n r＝0.184、0.142，均n P0.05)。铁、铜、镁水平均与IgA、IgG、IgM无明显相关(均n P>0.05)。n 结论:锌缺乏可以造成体液免疫IgA、IgG减少，可能与儿童反复感染有关。“,”Objective:To investigate the levels of trace elements(iron, zinc, magnesium and copper) in 0~9 years old children in Shenyang, and to explore the relationship between trace elements and humoral immunity(IgA, IgG and IgM).Methods:From September 2018 to October 2019, retrospective analysis was performed in children aged 0-9 who admitted to the Fourth Hospital Affiliated to China Medical University and underwent trace elements and humoral immunity(IgA, IgG and IgM).Results:A total of 422 children met the criteria, including 228 boys and 194 girls.The rates of iron deficiency in children aged 0-3, 4-6 and 7-9 were 17.5%, 18.2% and 14.0%, respectively, and zinc deficiency rates were 10.0%, 9.0% and 10.5%, respectively.There were no statistically significant differences in the rates of iron deficiency and zinc deficiency in each age group(χn 2=0.520, n P>0.05; χn 2=0.135, n P>0.05). Magnesium and copper levels in all children were in the normal range.The levels of IgA and IgG [(1.24±0.77)g/L, (9.07±3.04)g/L] in the zinc deficiency group were significantly lower than those in the normal group [(0.94±0.55)g/L, (8.18±2.11)g/L], the differences were statistically significant(n t=-2.858, -2.440, all n P0.05). There were no statistically significant differences in IgA, IgG and IgM levels between the iron deficiency group and the iron normal group(n t=-1.346, -0.960, 0.029, all n P>0.05). There was a significant positive correlation between zinc level and IgA, IgG levels(n r=0.184, 0.142, all n P0.05). Iron, copper and magnesium levels were not significantly correlated with IgA, IgG and IgM levels(n P>0.05).n Conclusion:Deficiency of zinc can cause reduction of IgA and IgG, which may be related to repeated infection in children.