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CD4~+辅助T(Th)细胞在抗原的刺激下会分化为不同的效应T细胞亚群。体液免疫应答具有很好的持久性,持久性的维持依赖于一群特殊的CD4~+T细胞提供辅助,即滤泡辅助性T(Tfh)细胞。树突状细胞(DC)提呈抗原并促进活化的Tfh前体细胞迁移到B细胞滤泡区域分化为成熟的Tfh细胞,辅助生发中心(GC)形成以及浆细胞和记忆性B细胞的分化,从而形成完整的体液免疫应答。Tfh细胞分化和功能上的失调均会导致多种疾病的发生。本文主要从Tfh细胞分化、功能以及在疾病中的作用三个方面对Tfh细胞的研究进展进行阐述。
CD4 ~ + helper T (Th) cells differentiate into different effector T-cell subsets upon antigen stimulation. The humoral immune response has good persistence and persistence depends on the availability of a specific group of CD4 ~ + T cells, follicular helper T (Tfh) cells. Dendritic cells (DCs) present antigens and promote the migration of activated Tfh precursor cells to the B cell follicular region to differentiate into mature Tfh cells, assist in germinal center (GC) formation and differentiation of plasma cells and memory B cells, Thus forming a complete humoral immune response. Tfh cell differentiation and functional disorders will lead to a variety of diseases. This article mainly expounds the research progress of Tfh cells from Tfh cell differentiation, function and role in disease.