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目的比较雷贝拉唑、果胶铋、左氧氟沙星、呋喃唑酮组成的四联10 d疗法与传统三联疗法根除复发性幽门螺杆菌(Hp)感染的疗效。方法将经电子胃镜检查确诊为伴胃黏膜萎缩、糜烂的慢性胃炎患者98例随机分为两组:治疗组(A组,50例)方案为雷贝拉唑+果胶铋+左氧氟沙星+呋喃唑酮,疗程10d;对照组(B组,48例),三联疗法为奥美拉唑+阿莫西林+克拉霉素。结果治疗组有效率94%,Hp根除率88%;对照组有效率79%,Hp根除率78%。两组比较差异有统计学意义(P<0.05)。结论雷贝拉唑+果胶铋+左氧氟沙星+呋喃唑酮组成的10d疗法治疗复发性Hp阳性胃炎具有疗效确切,安全,依从性好的特点
Objective To compare the curative effect of quadruple 10-day therapy consisting of rabeprazole, pectin bismuth, levofloxacin and furazolidone with traditional triple therapy for the eradication of recurrent Helicobacter pylori (Hp) infection. Methods Ninety-eight patients with chronic gastritis diagnosed as gastric mucosal atrophy and erosions by electronic gastroscopy were randomly divided into two groups: treatment group (group A, 50 cases) with rabeprazole + pectin bismuth + levofloxacin + furazolidone, Treatment 10d; control group (B group, 48 cases), triple therapy for omeprazole + amoxicillin + clarithromycin. Results In the treatment group, the effective rate was 94% and the Hp eradication rate was 88%. In the control group, the effective rate was 79% and the Hp eradication rate was 78%. The difference between the two groups was statistically significant (P <0.05). Conclusions The 10d therapy consisting of rabeprazole + pectin bismuth + levofloxacin + furazolidone has the characteristics of definite curative effect, safe and good compliance in treatment of recurrent Hp-positive gastritis