本发明公开了一种高纯度丁酸氯维地平的制备方法,是以3-氨基巴豆酸氰乙酯和2,3-二氯亚苄基乙酰乙酸甲酯为起始原料,经环合、水解、脱色和酸化析晶制得中间体—4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-5-甲氧基羰基-3-吡啶羧酸;所述中间体再与正丁酸氯甲酯缩合、精制得到高纯度丁酸氯维地平。本发明工艺简捷,操作方便,收率高,成 The invention discloses a method for preparing high-purity clevidipine butyrate, which comprises the following steps: taking cyanoethyl 3-aminocrotonate and methyl 2,3-dichlorobenzylideneacetoacetate as starting materials, Hydrolysis, decoloration and acidification gave Intermediate 4- (2,3-dichlorophenyl) -1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridine Carboxylic acid; the intermediate is then condensed with chloromethyl butyrate to obtain high-purity clevidipine butyrate. The invention has the advantages of simple process, convenient operation and high yield