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目的探讨哌拉西林钠舒巴坦钠持续静滴治疗重症肺炎的临床疗效和安全性。方法选取2012年6月—2014年2月内蒙古林业总医院收治的重症肺炎90例,随机分为治疗组(46例)和对照组(44例)。治疗组患者首先给予注射用哌拉西林钠舒巴坦钠5.0 g溶入到200 m L生理盐水中,1 h内静滴完,然后将注射用哌拉西林钠舒巴坦钠5.0 g溶入至20 m L生理盐水中,将微量泵泵入速度调整为2 m L/h持续泵入,2次/d。对照组静脉滴注注射用哌拉西林钠舒巴坦钠5.0 g溶入至200m L生理盐水中,1 h静滴完,每8小时一次。两组均持续治疗3 d以上。比较两组的临床疗效,同时比较两组咳嗽消失时间、啰音消失时间、体温恢复正常时间、白细胞恢复正常时间。结果治疗后,治疗组和对照组的总有效率分别为80.44%、59.09%,两组总有效率比较差异有统计学意义(P<0.05)。治疗组咳嗽消失时间、啰音消失时间、体温恢复正常时间、白细胞恢复正常时间均显著短于对照组,两组比较差异有统计学意义(P<0.05)。结论哌拉西林钠舒巴坦钠持续静滴对重症肺炎有较好的临床疗效,可缩短各观察指标的时间,值得临床推广应用。
Objective To investigate the clinical efficacy and safety of piperacillin-sodium and sulbactam sodium in the treatment of severe pneumonia. Methods 90 patients with severe pneumonia admitted in Inner Mongolia Forestry General Hospital from June 2012 to February 2014 were randomly divided into treatment group (46 cases) and control group (44 cases). In the treatment group, 5.0 g of piperacillin sodium and sulbactam sodium for injection was first dissolved in 200 ml normal saline for 1 hour, and then 5.0 g of piperacillin sodium and sulbactam sodium for injection was dissolved To 20 m L of saline, the pump speed will be adjusted to 2 m L / h continuous pumping, 2 times / d. Control group intravenous infusion of piperacillin sodium sulbactam sodium 5.0 g dissolved into 200m L normal saline, 1 h intravenously, every 8 hours. Both groups continued treatment for more than 3 days. The clinical curative effect was compared between the two groups. At the same time, the disappearance time of cough, the disappearance of rales, the normal time of body temperature recovery and the normal time of leukocyte recovery were compared. Results After treatment, the total effective rates of the treatment group and the control group were 80.44% and 59.09%, respectively. There was significant difference between the two groups in the total effective rate (P <0.05). Treatment group cough disappear time, rales disappear time, body temperature returned to normal time, normal white blood cell recovery time were significantly shorter than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion Piperacillin sodium and sulbactam sodium continued intravenous infusion of severe pneumonia has a better clinical efficacy, can shorten the time of each observation index, worthy of clinical application.