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Dab2/DOC-2是具有信号转导功能的磷蛋白,在丝裂原信号转导途径中起作用,通过蛋白质的相互作用和蛋白磷酸化发挥作用,参与控制细胞生长的信号通路而发挥生长抑制效应,Dab2/DOC-2又作为胞质衔接蛋白,参与细胞内蛋白运输。在肿瘤中纯合子基因缺失时被激活,是抑癌基因的候选成员。其在多种肿瘤中低或失表达,如卵巢癌,乳腺癌,绒毛膜癌和前列腺癌等,重新表达能抑制肿瘤的生长。Dab2也在胚胎的发生过程中发挥重要的作用。
Dab2 / DOC-2 is a phosphoprotein that functions as a signal transducer and plays a role in the mitogen signal transduction pathway. It functions through protein-protein interactions and protein phosphorylation and participates in the signal transduction that controls cell growth to exert growth inhibition Effect, Dab2 / DOC-2 as a cytoplasmic adapter protein involved in intracellular protein transport. The homozygous gene is activated in the absence of the tumor, is a candidate member of the tumor suppressor gene. Its expression in a variety of low or low tumor, such as ovarian cancer, breast cancer, choriocarcinoma and prostate cancer, re-expression can inhibit tumor growth. Dab2 also plays an important role in embryogenesis.