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目的：探讨病毒性肝炎患者血浆神经肽的变化规律及其意义。方法：用放射免疫法（ Ｒ Ｉ Ａ）检测了６７ 例各型肝炎患者及１０ 名正常人血浆亮啡肽、神经肽 Ｙ 含量。结果：各型肝炎患者急性肝炎、慢重肝、慢肝重度和中度血浆亮啡肽含量显著高于正常对照组（ Ｐ＜ ０．０５），且慢重肝和慢肝重度显著高于其他各组（ Ｐ＜ ０．０１）。神经肽 Ｙ 显著低于慢肝轻度和正常对照组（ Ｐ＜ ０．０１）。在慢性肝病者中，血浆亮啡肽与血清总胆红素呈正相关，与清蛋白和凝血酶原活动度呈负相关，而神经肽 Ｙ 与之相反。结论：病毒性肝炎患者血浆亮啡肽显著升高，而神经肽 Ｙ 显著降低，并与肝损害程度基本一致。推测该两种神经肽可能参与了病毒性肝炎的病理损害过程，并与某些临床症状有关，可作为评价肝功能的一项辅助指标。
Objective: To investigate the changes of plasma neuropeptides in patients with viral hepatitis and its significance. Methods: The plasma levels of leupeptin and neuropeptide Y in 67 patients with hepatitis and 10 normal controls were detected by radioimmunoassay (RIA). Results: The levels of acute hepatitis, chronic severe hepatitis, chronic severe hepatitis and moderate plasma levels of leupeptin in patients with various types of hepatitis were significantly higher than those in normal controls (P <0.05), and those in chronic severe hepatitis and chronic liver were significantly higher than those in other Group (P <0.01). Neuropeptide Y was significantly lower than the mild and normal control group (P <0.01). In patients with chronic liver disease, plasma leupeptin was positively correlated with serum total bilirubin, negatively correlated with albumin and prothrombin activity, whereas neuropeptide Y was the opposite. Conclusions: Plasma leucovorin was significantly elevated in patients with viral hepatitis, whereas neuropeptide Y was significantly reduced and consistent with the degree of liver damage. It is speculated that the two neuropeptides may be involved in the pathological process of viral hepatitis, and with some clinical symptoms, can be used as a secondary indicator of liver function evaluation.