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应用EL ISA法测定158例乳腺癌、51例乳腺良性疾病及43例健康体检者血清肿瘤相关抗原153(CA 153)、癌胚抗原(CEA)水平,用光电比色法检测血清恶性肿瘤特异性生长因子(TSGF)水平。结果初治、治疗无效及复发转移的乳腺癌患者血清CA 153、CEA、TSGF水平均明显高于乳腺良性疾病、健康体检者和治疗显效组的水平;上述3项指标联合检测的敏感性及准确性高于任意两项联合检测或单项检测,而特异性以CA 153为最高。认为上述三项指标联合检测对判断乳腺癌预后及监控其复发和转移有较高的应用价值。
Serum tumor-associated antigen 153 (CA 153) and carcinoembryonic antigen (CEA) levels in 158 cases of breast cancer, 51 cases of benign breast diseases and 43 cases of healthy subjects were measured by ELISA. The specificity of serum malignant tumor Growth factor (TSGF) levels. Results The serum levels of CA153, CEA and TSGF were significantly higher in breast cancer patients with initial treatment, ineffective treatment and recurrence and metastasis than those in benign breast disease, healthy physical examination and treatment-effective group. The sensitivity and accuracy of these three combined tests Sex is higher than any two combined tests or single tests, while specificity is highest with CA 153. It is considered that the combined detection of the above three indexes has high value in judging the prognosis of breast cancer and monitoring its recurrence and metastasis.