论文部分内容阅读
本文报道国产头孢三嗪对临床分离的836株需氧菌和53株厌氧菌的抗菌活性测定,一并与其他6种头孢菌素(头孢噻肟、去乙酰头孢噻肟、进口头孢三嗪、头孢哌酮、头孢唑肟、Ceftazi-dime)和庆大霉素相比较.191株革蓝氏阳性球菌中,头孢三嗪对肺炎球菌、草绿色链球菌和溶血性链球菌的MIC_(90)≤0.06μg/ml,对金黄色葡萄球菌不产酶株及产酶株的MIC_(90)分别为4和16μg/ml,肠球菌对本品多数耐药.头孢三嗪对流感杆菌、多数肠杆菌科细菌如大肠杆菌、肺炎杆菌、拘橼酸杆菌、产气杆菌、变形杆菌、沙门氏菌、痢疾杆菌和阴沟杆菌等具有显著抗菌活性,其MIC_(90)≤0.06～0.5μg/ml,显著优于庆大霉素.头孢三嗪对绿脓杆菌虽有一定作用,但不如Ceftazidime和头孢哌酮.本品对不动杆菌属如硝酸盐阴性杆菌以及产碱杆菌等活性较差.除脆弱类杆菌外.头孢三嗪对厌氧球菌和厌氧杆菌均有一定抗菌活性.进口头孢三嗪与国产头孢三嗪的抗菌活性无显著差别.所测试的6种头孢菌素除了去乙酰头孢噻肟外,对肠杆菌科细菌均有强大活性;细菌对庆大霉素的耐药率较高,285株庆大霉素耐药菌株中,对头孢三嗪敏感者占201株(70.5%);84株头孢三嗪耐药菌中主要为绿脓杆菌(63株)和硝酸盐阴性杆菌(11株),其他菌10株.
This article reports the antibacterial activity of domestic cefotaxime against 836 aerobic bacteria and 53 anaerobic bacteria isolated from clinical isolates. The antibacterial activity of ceftriaxone against 6 kinds of cephalosporins (cefotaxime, cefotaxime, cefotaxime, , Cefoperazone, ceftizoxime, Ceftazi-dime) and gentamicin.Among191 strains of gram-positive cocci, the MIC 90 of cefotaxime against Streptococcus pneumoniae, Streptococcus viridans and Streptococcus hemolyticus ) ≤ 0.06μg / ml, Staphylococcus aureus non-enzyme-producing strains and enzyme-producing strains MIC_ (90) were 4 and 16μg / ml, enterococci most of the goods resistant to ceftriaxime on the flu bacilli, the majority Enterobacteriaceae such as Escherichia coli, Klebsiella pneumoniae, Citrobacter citrinum, Aerobacter aerogenes, Proteus, Salmonella, Shigella and Enterobacter cloacae have significant antibacterial activity, the MIC 90 (90) ≤ 0.06 ~ 0.5μg / ml, significant Is better than gentamicin.Cemectin triazine Pseudomonas aeruginosa has a certain role, but not as good as Ceftazidime and cefoperazone.This product on the Acinetobacter such as nitrate-negative bacilli and Alcaligenes activity is worse.In addition to fragile Bacteroides outside the ceftriaxone anaerobic bacteria and anaerobic bacteria have a certain Antibacterial activity.And imported ceftriaxone and domestic ceftriaxone antibacterial activity no significant difference.The tested 6 kinds of cephalosporins in addition to deacetyl cefotaxime, the Enterobacteriaceae bacteria have strong activity; bacteria against Gentamicin Among the 285 gentamicin-resistant isolates, 201 (70.5%) were sensitive to ceftriaxone, while 84 cefotaxime-resistant isolates were predominantly Pseudomonas aeruginosa (63 isolates ) And nitrate-negative bacilli (11 strains), other strains of 10 strains.