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目的观察还原型谷胱甘肽对抗结核药物引起的药物性肝损害的疗效。方法 174例由抗结核药物引起的药物性肝损害患者均停用抗结核治疗药物,在护肝治疗基础上分别应用还原型谷胱甘肽(观察组)和甘草酸二铵(对照组)治疗,4周后对两组患者肝损害情况及预后进行分析比较。结果观察组在肝功能改善方面优于对照组(P<0.05);观察组总有效率89.8%,对照组67.4%(P<0.01)。结论还原型谷胱甘肽有很好的保肝、降酶作用。
Objective To observe the effect of reduced glutathione on drug-induced liver damage caused by anti-tuberculosis drugs. Methods A total of 174 anti-tuberculosis drugs were discontinued in 174 patients with drug-induced liver damage caused by anti-tuberculosis drugs. On the basis of hepatoprotective therapy, glutathione (observation group) and diammonium glycyrrhizinate (control group) , 4 weeks after the two groups of patients with liver damage and prognosis were analyzed and compared. Results The observation group was better than the control group in improving liver function (P <0.05). The total effective rate was 89.8% in the observation group and 67.4% in the control group (P <0.01). Conclusion Reduced glutathione has a good liver, reducing enzyme.