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目的探讨宫颈糜烂患者中超薄液基细胞学检测(TCT)结果正常者人乳头瘤状病毒(HPV)的感染状况。方法 316例宫颈糜烂且TCT检测结果均正常的患者,采用基因扩增和导流杂交技术,进行HPV基因分型检测,分析该群体中HPV的感染率及病毒分型状况。结果该群体中HPV感染者96例(感染率为30.4%),重度糜烂比轻度糜烂感染率高(P<0.05),以单一病毒亚型感染为主,感染率最高的为16亚型;多重感染者中,感染率最高的为18与53亚型。结论尽管宫颈糜烂患者TCT正常,但HPV的感染率仍然较高,因此对宫颈糜烂患者实施HPV检测,将有利于对宫颈癌高危人群的筛查与监测。
Objective To investigate the infection status of human papillomavirus (HPV) in patients with cervical erosion who have normal TCT results. Methods 316 cases of cervical erosion and TCT test results were normal, using gene amplification and flow-through hybridization, HPV genotyping test, analysis of the population HPV infection and virus typing. Results Ninety-six cases of HPV infection (30.4%) were found in this group. The rate of severe erosion was higher than that of mild erosion (P <0.05). The most common infection was single subtype 16 virus. Of the multiple infections, the highest rates of infection were 18 and 53 subtypes. Conclusion Although the TCT of patients with cervical erosion is normal, the infection rate of HPV is still high. Therefore, the implementation of HPV testing in patients with cervical erosion will be helpful for the screening and monitoring of cervical cancer at high risk.