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目的探讨痰热清注射液联合抗生素治疗支气管肺炎患儿的临床效果及其对C-反应蛋白(CRP)水平的影响。方法 60例支气管肺炎患儿随机分为治疗组和对照组,两组患儿均给予常规抗生素治疗,治疗组在常规抗生素治疗的基础上给予痰热清注射液治疗,两组疗程为7～10 d。评价两组临床疗效,观察不良反应,采用透射比浊法测定CRP水平。结果治疗组临床疗效总有效率为96.7%,显著高于对照组(86.7%),相比较差异有统计学意义(P<0.05);治疗后,两组CRP水平与治疗前比较均显著下降,相比较差异有统计学意义(P<0.05),且治疗组与对照组比较差异有统计学意义(P<0.05);两组均未发生明显的不良反应。结论痰热清注射液联合抗生素治疗支气管肺炎患儿是一种安全、有效的治疗方法,并且能明显地降低患儿血清中CRP浓度,临床值得推广应用。
Objective To investigate the clinical effects of Tanreqing Injection combined with antibiotics in children with bronchopneumonia and its effect on C-reactive protein (CRP) levels. Methods Sixty children with bronchopneumonia were randomly divided into treatment group and control group. Both groups were given conventional antibiotics. The treatment group was treated with Tanreqing Injection on the basis of conventional antibiotic therapy. The treatment course was 7-10 d. The clinical curative effect was evaluated, the adverse reaction was observed, and the CRP level was determined by transmission nephelometry. Results The total effective rate of the treatment group was 96.7%, significantly higher than that of the control group (86.7%), the difference was statistically significant (P <0.05); after treatment, CRP levels in both groups were significantly decreased compared with those before treatment, (P <0.05), and the difference between the treatment group and the control group was statistically significant (P <0.05). No significant adverse reactions occurred in both groups. Conclusion Tanreqing injection combined with antibiotics in the treatment of children with bronchial pneumonia is a safe and effective treatment, and can significantly reduce the serum CRP concentrations in children, the clinical worthy of promotion and application.