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血红蛋白病血红蛋白病包括异常血红蛋白病和地中海贫血两大类。由于分子病理学的阐明,这两类疾病有时难以分出明确的界限。一、异常血红蛋白病异常血红蛋白是由于珠蛋白结构基因突变导致珠蛋白结构发生变异的血红蛋白。已发现的异常血红蛋白约450种。据1984年统计,已在我国28个省市自治区、30余个少数民族中进行普查,调查发生率为0.309%。已发现12种新型。最多见的异常血红蛋白为HbE。
Hemoglobinopathies Hemoglobinopathies include two major categories of abnormal hemoglobinopathy and thalassemia. Due to the elucidation of molecular pathology, it is sometimes difficult to draw a definite line between these two types of diseases. First, abnormal hemoglobin disease abnormal hemoglobin is due to globin structural gene mutation led to structural variation of globin hemoglobin. Abnormal hemoglobin has been found about 450 species. According to the statistics of 1984, the census has been carried out in over 28 ethnic minorities in 28 provinces, autonomous regions and municipalities in China. The survey incidence was 0.309%. Twelve new types have been found. The most common abnormal hemoglobin is HbE.