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目的 :观察脑力智宝对神经细胞损伤的影响。方法 :采用血清药理学方法 ,体外培养PC12细胞 ,研究脑力智宝对兴奋性氨基酸和一氧化氮引起的PC12细胞损伤的影响。结果 :脑力智宝提取物及其含药血清可明显地对抗兴奋性氨基酸和一氧化氮引起的PC12细胞形态改变 ,降低胞外乳酸脱氢酶活性 ,增加细胞存活率。结论 :脑力智宝提取物及其含药血清对兴奋性氨基酸和一氧化氮引起的PC12细胞损伤具有保护作用
Objective : To observe the effect of Naoli Zhibao on nerve cell injury. Methods: Using serum pharmacology, PC12 cells were cultured in vitro to study the effects of Naoli Zhibao on the injury of PC12 cells induced by excitatory amino acids and nitric oxide. RESULTS : The Naolizhibao extract and its drug-containing serum could significantly inhibit the morphological changes of PC12 cells induced by excitatory amino acids and nitric oxide, reduce extracellular lactate dehydrogenase activity and increase cell survival rate. Conclusion :Naolitic Zhibao extract and its drug-containing serum have protective effects on excitatory amino acids and nitric oxide induced PC12 cell injury