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目的观察他汀类药物短期应用对慢性心力衰竭患者心功能、细胞因子(C反应蛋白、脑利尿钠肽)水平的影响。方法将106例慢性心力衰竭患者(NYHA分级Ⅱ～Ⅲ级)随机分为两组,治疗组(54例)和对照组(52例),两组都给予β受体阻滞剂、ACEI、利尿剂及地高辛治疗,治疗组再给予辛伐他汀40mg,每晚一次,共服6个月,治疗前后检查心脏彩超,评价心功能,测定C反应蛋白、脑利尿钠肽及血脂水平。结果 6个月后治疗组低密度脂蛋白、胆固醇水平明显降低,心功能有明显改善(P<0.01),左室射血分数有明显提高(P<0.01),C反应蛋白、脑利尿钠肽有明显的降低(P<0.01),而对照组前后无明显改变。结论辛伐他汀能降低血浆细胞因子(C反应蛋白、脑利尿钠肽)水平,改善心功能,有利于慢性心力衰竭的治疗。
Objective To observe the effects of short-term statins on cardiac function, cytokines (C-reactive protein and brain natriuretic peptide) in patients with chronic heart failure. Methods 106 patients with chronic heart failure (NYHA grade Ⅱ ~ Ⅲ grade) were randomly divided into two groups: treatment group (54 cases) and control group (52 cases). Both groups were given β - blockers, ACEI, And digoxin treatment. The treatment group was given simvastatin 40mg once a night for a total of 6 months. The echocardiography was performed before and after treatment to evaluate the cardiac function. The levels of C-reactive protein, brain natriuretic peptide and blood lipid were measured. Results After 6 months, the levels of LDL and cholesterol in the treatment group were significantly decreased, the cardiac function was significantly improved (P <0.01), the left ventricular ejection fraction was significantly increased (P <0.01), C-reactive protein and brain natriuretic peptide There was a significant reduction (P <0.01), while the control group before and after no significant change. Conclusion Simvastatin can reduce the level of plasma cytokines (C-reactive protein, brain natriuretic peptide), improve cardiac function, which is beneficial to the treatment of chronic heart failure.