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本实验用大鼠静脉注射内生致热原（ＥＰ）复制发热模型。观察发热反应及发热不同时相、不同胞区精氨酸加压素（ＡＶＰ）和亮氨酸脑啡肽（Ｌ－ＥＫ）含量的变化。结果表明：大鼠ＥＰ双相热时下丘脑组织ＡＶＰ含量在双峰热的两个高峰期和体温恢复期均明显高于对照组，ＡＶＰ含量与发热第一时相和第二时相体温升高有相关关系。而脑干和大脑皮质组织中ＡＶＰ含量则无明显变化。下丘脑组织、脑干组织中Ｌ－ＥＫ含量在双峰热的两个高峰期均高于对照组，恢复期脑干组织中Ｌ－ＥＫ含量仍高于对照组。大脑皮质组织中Ｌ－ＥＫ含量无明显变化。提示ＥＰ性发热时中枢的ＡＶＰ和Ｌ－ＥＫ可能参与体温调节反应。
In this study, rats were injected intravenously with endogenous pyrogen (EP) replication fever model. The change of arginine vasopressin (AVP) and leucine enkephalin (L-EK) in different phases of fever and fever were observed. The results showed that the content of AVP in hypothalamus tissue of EP rats was significantly higher than that of the control group in both peak and bodily recovery phases of bimodal heat. The AVP content was significantly higher in the first phase of fever and the second phase of body temperature There is a relationship. The brain stem and cerebral cortex tissue AVP content was no significant change. The contents of L-EK in hypothalamus and brainstem tissue were both higher than those in control group during the two peak periods of bimodal heat, while the content of L-EK in brain stem tissue during convalescence was still higher than that of control group. There was no significant change in L-EK content in cerebral cortex. Tip EP fever central AVP and L-EK may be involved in the thermoregulatory response.