【摘 要】
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Background Retinol binding protein 4 (RBP4),as an adipocyte secreted cytokine,was recently found to be inversely correlated with expression of glucose transport
【机 构】
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Department of Endocrinology
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Background Retinol binding protein 4 (RBP4),as an adipocyte secreted cytokine,was recently found to be inversely correlated with expression of glucose transporter 4 (GLUT4) in insulin resistance (IR) state and to have an intimate relationship with IR and type 2 diabetes mellitus (T2DM).The present study aimed to evaluate the anti-diabetic efficacy of cinnamaldehyde (tin),berberine (Bet),and metformin (Met) as well as their impacts on the RBP4-GLUT4 system.Methods Rat models of T2DM were established by combination of intraperitoneal injection of low-dose streptozotocin and high fat diet induction.Rats were divided into five groups:the control group,the diabetes group,the diabetes+Ber group,the diabetes+Cin group,and the diabetes+Met group.Western blotting was used to detect the serum or tissue RBP4 and GLUT4 protein levels.Results After treatment for four weeks,both Cin and Ber displayed significant hypolipidemic,hypoglycemic,and insulin sensitizing functions (P
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