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目的 :观察肝得宁胶囊对实验性肝损伤的保护作用。方法 :应用四氯化碳 ( CCl4)、D-半乳糖胺 ( D-Gala)化学性肝损伤动物模型 ,以肝功能和病理改变为判断指标 ,对肝得宁胶囊的保肝作用进行实验。结果 :肝功能检测结果表明 ,肝得宁胶囊 0 .1875 g· kg- 1 ,和 0 .3 75 g· kg- 1均显著降低 CCl4,D-Gala化学性肝损伤小鼠血中谷丙转氨酶 ( AL T)的含量 ,与阳性药联苯双酯相比 ,无显著性差异 ( P>0 .0 5 )。肝病理镜检证实 ,该药有减轻中毒小鼠肝细胞的变性、坏死作用。结论 :肝得宁胶囊对化学性肝损伤有明显的保护作用 ,其疗效与肝得宁丸剂结果相似 ,是安全有效的抗肝炎中成药
Objective : To observe the protective effect of Gandening capsule on experimental hepatic injury. METHODS: The animal models of chemical liver injury induced by carbon tetrachloride (CCl4) and D-galactosamine (D-Gala) were used. The liver function and pathological changes were used as indicators to evaluate the hepatoprotective effect of Gandening Capsule. RESULTS: Liver function test results showed that GDD capsules (0.117 g·kg-1) and 0.375 g·kg-1 significantly reduced the serum alanine aminotransferase in mice with chemical liver injury induced by CCl4 and D-Gala ( The content of AL T) was not significantly different from that of the positive drug bifendate (P>0.05). Liver pathological examination confirmed that the drug can reduce the degeneration and necrosis of liver cells in poisoned mice. Conclusion : Gandening capsule has obvious protective effect on chemical liver injury, and its efficacy is similar to that of Gandening Pill. It is a safe and effective Chinese medicine for anti-hepatitis.