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符合入选标准的60例糖尿病周围神经病变患者,随机分为A组(静脉滴注α-硫辛酸注射液600mg,1次/天,同时口服依帕司他片50mg/次,3次/天),B组(静脉滴注α-硫辛酸注射液600mg,1次/天),连续用药2周。治疗前后分别记录TCSS评分、神经症状评分、神经反射评分及感觉功能评分。结果两组患者治疗后TCSS评分、神经症状评分、神经反射评分及感觉功能评分均较治疗前显著降低(P<0.05);A组患者神经症状评分改善程度较B组大(P<0.05),神经反射与感觉功能评分改善程度两组无统计学差异(P>0.05)。结论α-硫辛酸联合依帕司他片治疗糖尿病周围神经病变是有效的,联合治疗组患者主观症状改善较单一治疗组明显。
Sixty patients with diabetic peripheral neuropathy who met the inclusion criteria were randomly divided into group A (intravenous infusion of α-lipoic acid 600mg once a day, at the same time, oral eplerenia tablets 50mg / time, 3 times / day) , B group (intravenous infusion of α-lipoic acid 600mg, 1 / day) for 2 weeks. TCSS score, neurological symptom score, neurological reflex score and sensory function score were recorded before and after treatment. Results The scores of TCSS, neurological symptoms, neurological reflex scores and sensory function scores of the two groups were significantly lower than those before treatment (P <0.05). The scores of neurological symptoms in group A were significantly better than those in group B (P <0.05) There was no significant difference between the two groups in neurological reflex and sensory function scores (P> 0.05). Conclusion The combination of α-lipoic acid and epalrestat in the treatment of diabetic peripheral neuropathy is effective. The improvement of subjective symptoms in the combined treatment group is more obvious than that in the single treatment group.