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目的比较原发性高血压患者使用西尼地平与非洛地平的降压效果及对自主神经功能的影响。方法轻中度原发性高血压患者随机分为西尼地平组(n=38,西尼地平10mg,每日1次)与非洛地平组(n=36,非洛地平5mg,每日1次),治疗3个月后,比较两组血压与心率的改变,用动态心电图进行能量光谱分析。结果西尼地平与非洛地平均有良好降压作用,但西尼地平对心率无明显的影响,而非洛地平增加心率,并使白天与夜晚RR间期低频/高频(LF/HF)比率明显增加,西尼地平仅在白天有增加。结论西尼地平对轻中度原发性高血压有良好降压疗效,且不增加交感神经活性,为有利于防止心脏事件发生的新型钙通道阻滞剂。
Objective To compare the antihypertensive efficacy of cilnidipine and felodipine in patients with essential hypertension and their effects on autonomic nervous system function. Methods Patients with mild to moderate essential hypertension were randomly divided into the cilnidipine group (n = 38, cilnidipine 10 mg once daily) and the felodipine group (n = 36, felodipine 5 mg daily Times). After 3 months of treatment, the changes of blood pressure and heart rate were compared between the two groups, and energy spectrum analysis was performed by using dynamic electrocardiogram. Results Both cilnidipine and felodipine had a good antihypertensive effect on average, but cilnidipine had no significant effect on heart rate, whereas felodipine increased heart rate and reduced daytime and night RR / LF / HF (LF / HF) The rate was significantly increased and cilnilipid only increased during the day. Conclusion Cilnidipine has a good antihypertensive effect on mild to moderate essential hypertension, and does not increase the sympathetic nerve activity, which is a new type of calcium channel blocker for preventing the occurrence of cardiac events.