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目的探讨腹腔热灌注联合全身静脉化疗在胃癌术后的临床效果。方法回顾性分析我院收治的88例胃癌手术患者的临床资料,根据术后化疗方法分为治疗组和对照组各44例,治疗组采用腹腔热灌注化疗联合全身静脉化疗进行治疗,对照组仅采用静脉化疗治疗,比较两组患者术后2个月-5年内的生存率、复发率、转移率情况及不良反应发生情况。结果术后2年内治疗组患者的生存率略高于对照组,但差异无统计学意义,P>0.05,术后3年、5年治疗组的生存率均高于对照组,差异有统计学意义,P<0.05;治疗组术后的总复发率及转移率显著低于对照组,P<0.05;两组不良反应无显著差异,P>0.05。结论腹腔热灌注联合全身静脉化疗用于胃癌术后可显著提高生存率,明显降低术后复发率和转移率,毒副作用小。
Objective To investigate the clinical effect of intraperitoneal hyperthermic perfusion combined with systemic vein chemotherapy after gastric cancer surgery. Methods The clinical data of 88 patients with gastric cancer who underwent surgery in our hospital were retrospectively analyzed. According to the postoperative chemotherapy, the patients were divided into treatment group (44 cases) and control group (44 cases). The treatment group was treated with intraperitoneal hyperthermic chemotherapy combined with systemic vein chemotherapy. The patients were treated with intravenous chemotherapy. The survival rate, recurrence rate, metastasis rate and incidence of adverse reactions in two groups were compared between two months and five years after operation. Results The survival rate of the treatment group was slightly higher than that of the control group within 2 years after operation, but the difference was not statistically significant (P> 0.05). The survival rates of the 3-year and 5-year treatment groups were significantly higher than those of the control group Significance, P <0.05; The total recurrence rate and metastasis rate of the treatment group was significantly lower than that of the control group, P <0.05; There was no significant difference between the two groups (P> 0.05). Conclusion Intraperitoneal hyperthermic perfusion combined with systemic intravenous chemotherapy for gastric cancer can significantly improve the survival rate, significantly reduce postoperative recurrence rate and metastasis rate, small toxic side effects.