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目前,AT1受体自身抗体在高血压及妊高征患者血清中有较高的检出率,并且认为该抗体有类似血管紧张素II的激动样作用,即能够与AT1受体结合后使之产生兴奋性效应,如细胞增殖、血管壁增厚及靶器官重构等等。因此血管紧张素II受体拮抗剂通过阻断AT1受体,选择性强,从而起到了比ACEI更
Currently, AT1 receptor autoantibodies have a high detection rate in the serum of patients with hypertension and PIH and the antibody is thought to have an agonistic effect similar to that of angiotensin II, ie, it binds to AT1 receptor Produce excitatory effects, such as cell proliferation, thickening of the vessel wall and target organ remodeling and more. Therefore, angiotensin II receptor antagonist by blocking the AT1 receptor, strong selectivity, which played a more ACEI