论文部分内容阅读
目的了解韶关地区孕产妇和新生儿配对麻疹抗体水平及0~8月龄婴儿麻疹抗体水平变化情况,为降低小月龄婴儿的麻疹发病率提供科学依据。方法选取韶关市妇幼保健院和南雄市人民医院作为监测医院,孕妇在医院分娩后,1d内采集新生儿断脐后近体端脐带血及其母血各100份;采用随机抽样的方法随机抽取未患过麻疹也未注射麻疹减毒活疫苗的8月龄以下健康婴儿为监测对象,分为1~、2~、3~、4~、5~、6~、7~8月龄共7个组,每组采集50例标本,分离血清后采用ELISA法进行麻疹Ig G抗体测定。结果 2007—2014年韶关地区共计报告麻疹病例206例,年平均发病率0.81/10万,其中<8月龄病例数72例,占34.95%。采集母婴配对标本各100份,母亲阳性标本89份,阳性率89.00%,新生儿阳性标本87份,阳性率87.00%,母亲与新生儿之间的阳性率差异无统计学意义(P>0.05);0~1月龄婴儿共采集标本450份,经过检测阳性标本数202份,阳性率44.90%,随月龄增加抗体水平迅速下降(P<0.05)。结论产妇麻疹抗体水平与新生儿麻疹抗体水平相关,胎传麻疹抗体随着年龄的增加迅速下降,初次麻疹疫苗免疫前基本失去保护作用。
Objective To understand the maternal and newborn paired measles antibody level and the measles antibody level in 0-8 months old infants in Shaoguan area and to provide a scientific basis for reducing the incidence of measles in babies of small age. Methods Shaoguan MCH and Nanxiong People’s Hospital were selected as monitoring hospitals. The pregnant women were collected 100 days after birth in the hospital within 1 day after birth. Umbilical cord blood and its maternal blood were collected from the umbilical cord of each newborn. Random sampling method The healthy babies under 8 months of age without measles or live attenuated measles vaccine were selected as the monitoring subjects and divided into 1 ~, 2 ~, 3 ~, 4 ~, 5 ~, 6 ~, 7 ~ 8 months old Seven groups were collected from each group. Fifty specimens were collected from each group. Serum IgA levels were determined by ELISA. Results A total of 206 cases of measles were reported in Shaoguan from 2007 to 2014, with an average annual incidence of 0.81 / 100 000, of which 72 cases (<34.95%) <8 months old. The maternal and paired samples were collected from 100 maternal positive samples, 89 maternal positive samples, the positive rate was 89.00%, 87 newborn positive samples, the positive rate was 87.00%, the positive rate between mothers and newborns was no significant difference (P> 0.05 ). A total of 450 specimens were collected from 0 to 1 month-old infants. After detecting 202 positive samples, the positive rate was 44.90%. The antibody level decreased rapidly with the increase of age (P <0.05). Conclusion The level of measles antibody in maternal age is related to the level of measles antibody in newborn. The antibody to measles in fetus is rapidly decreased with age. The initial measles vaccine has no protective effect before immunization.