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自身免疫性肝炎(AIH)常见于女性,表现为肝酶异常(转氨酶升高)、血清自身抗体如抗核抗体(ANA)、抗平滑肌抗体(SMA)、抗可溶性肝抗原抗体/肝胰抗原(SLA/LP)、抗肝肾微粒体抗体(LKM)1阳性和γ-免疫球蛋白升高,但并非所有AIH患者均出现上述特征。AIH的组织学特点为界面性肝炎,以浆细胞和淋巴细胞浸润为主,但无特征性组织学表现。AIH的确诊较为困难,目前的流行病学资料中报道的
Autoimmune hepatitis (AIH) is common in women and shows abnormal liver enzymes (elevated aminotransferases), serum autoantibodies such as antinuclear antibodies (ANAs), anti-smooth muscle antibodies (SMAs), anti-soluble liver antigens / hepatopancreas antigens SLA / LP), anti-hepatorenal microsomal antibody (LKM) 1 and elevated gamma-immunoglobulin, but not all AIH patients. The histological features of AIH are interfacial hepatitis, predominantly plasma cells and lymphocytes, but no characteristic histological findings. AIH is more difficult to diagnose and is reported in current epidemiological data