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目的:分析92例心房颤动(房颤)患者与C-反应蛋白(CRP)及其-717A>G多态性的关系。方法:采用免疫比浊法测定92例房颤患者(房颤组)和60例对照者(对照组)的血清CRP水平,同时应用聚合酶链反应检测CRP的-717A/G的基因多态性,结合其他临床资料分析。结果:Logistic回归分析显示自然对数转换CRP(In-CRP)水平(0R=7.84,P<0.01)与房颤独立相关,房颤组的水平显著高于对照组。2组-717A/G基因型的分布趋势相同,差异无统计学意义;但等位基因频数分布2组间存在显著性差异(χ2=4.38,P<0.05),G等位基因在房颤组中表现为低频率。CRP水平与-717A/G基因型无关,但AA基因型个体TC水平显著高于GA+GG型个体(P<0.05),但这种关系仅限于房颤患者。结论:血清CRP水平升高可能是房颤的独立危险因子,AA基因型在房颤组中表现为高TC水平,可能代表更高的炎症状态。
Objective: To analyze the relationship between C-reactive protein (CRP) and its -717A> G polymorphism in 92 patients with atrial fibrillation (AF). Methods: Serum CRP levels were measured in 92 patients with atrial fibrillation (AF group) and 60 controls (control group) by immunoturbidimetry, and the polymorphism of CRP -717A / G was detected by polymerase chain reaction , Combined with other clinical data analysis. Results: Logistic regression analysis showed that the level of In-CRP (0R = 7.84, P <0.01) was independently associated with atrial fibrillation, and the level of atrial fibrillation was significantly higher than that of the control group. There was no significant difference in the distribution of genotypes between the two groups - 717A / G, but there was significant difference between the two groups (χ2 = 4.38, P <0.05) In the performance of low frequency. The level of CRP was not related to the -717A / G genotype, but the TC level of AA genotype was significantly higher than that of GA + GG genotype (P <0.05), but the relationship was only limited to patients with AF. CONCLUSIONS: Increased serum CRP level may be an independent risk factor for atrial fibrillation. The AA genotype shows high TC level in AF group, which may represent a higher inflammatory state.