重症肌无力(MG)是由自身抗体介导的,主要导致神经肌肉接头处(NMJ)信号传导障碍的自身免疫性疾病.80%~90%的MG是由乙酰胆碱受体抗体(AchRAb)介导的,在MG患者血清中能检测到AchRAb的称为血清阳性重症肌无力(SPMG),而10%~20%的MG患者血清中未能检测到AchRAb,被称为血清阴性重症肌无力(SNMG).在SNMG中,有一部分患者血清中可检测到肌肉特异性激酶抗体 Myasthenia Gravis (MG) is an autoimmune disease mediated mainly by autoantibodies leading to neuromuscular junction (NMJ) signaling disorders, and 80% to 90% of MG is mediated by AchRAb , AchRAb was detected in the serum of MG patients as seronegative myasthenia gravis (SPMG), whereas AchRAb was undetectable in serum from 10% to 20% of MG patients, known as seronegative myasthenia gravis (SNMG ) In SNMG, a portion of patients’ serum detectable muscle-specific kinase antibodies