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目的:探讨尿毒清颗粒对慢性肾盂肾炎患者临床疗效的影响及其可能机制。方法:选择2015年5月~2016年5月于我院肾内科进行治疗的慢性肾盂肾炎患者60例,根据电脑生成的随机数字表将所有患者随机分为实验组与对照组,每组各30例。对照组患者给予头孢哌酮舒巴坦钠进行治疗,实验组患者在对照组的基础上联合使用尿毒清颗粒进行治疗。比较治疗前后两组患者血清转化生长因子-β1(TGF-β1)、肝细胞生长因子(HGF)、血清肌酐(Scr)、血尿素氮(BUN)及尿微量白蛋白水平的变化,并对治疗后的临床疗效进行评价。结果:与治疗前相比,两组患者治疗后的血清TGF-β1、Scr、BUN及尿微量白蛋白水平均显著降低,血清HGF水平均明显升高(P<0.05);与对照组相比,实验组患者治疗后的血清TGF-β1、Scr、BUN及尿微量白蛋白水平较低,血清HGF水平较高(P<0.05);临床总有效率较高(P<0.05)。结论:尿毒清颗粒能够提高慢性肾盂肾炎的临床疗效,可能与其降低患者血清TGF-β1及升高HGF水平有关。
Objective: To investigate the effect of Niaoduqing granule on the clinical curative effect of chronic pyelonephritis and its possible mechanism. Methods: Sixty patients with chronic pyelonephritis treated in our hospital from May 2015 to May 2016 were randomly divided into experimental group example. Patients in the control group were given cefoperazone sulbactam sodium for treatment. Patients in the experimental group were treated with the combination of nifu-qing granules on the basis of the control group. The changes of serum TGF-β1, HGF, Scr, BUN and urinary albumin in two groups were compared before and after treatment. After the clinical efficacy evaluation. Results: Compared with those before treatment, the levels of serum TGF-β1, Scr, BUN and urine microalbumin in both groups were significantly decreased and the levels of serum HGF were significantly increased (P <0.05). Compared with the control group The levels of serum TGF-β1, Scr, BUN and urine microalbumin in the experimental group were lower, serum HGF level was higher (P <0.05), and the total clinical effective rate was higher (P <0.05). Conclusion: Niaoduqing granule can improve the clinical curative effect of chronic pyelonephritis, which may be related to its reduction of serum TGF-β1 and increase of HGF.