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目的探讨强直性脊柱炎(AS)患者血清亲环素A(Cy PA)与临床疾病活动性指标间的相关性。方法收集2010年10月至2011年3月在广东省第二人民医院及中山大学附属第三医院首次确诊的活动期AS患者30例,健康志愿者(HV组)30名,以ELISA法检测两组血清Cy PA,比较两组间血清Cy PA的差异,并将AS患者血清Cy PA结果分别与红细胞沉降率(ESR)、C反应蛋白(CRP)、毕氏AS疾病活动指数(BASDAI)及近年新产生的AS疾病活动指数(ASDAS)进行Pearson相关分析。结果 AS组血清Cy PA明显高于HV组[(34.6±11.0)μg/m L对(22.7±8.0)μg/m L,P<0.05];相关分析提示AS组患者血清Cy PA水平与ESR(r=0.436,P<0.05)、CRP(r=0.463,P<0.05)、ASDAS-CRP(r=0.783,P<0.05)、ASDAS-ESR(r=0.762,P<0.05)均存在正相关,但与BASDAI(r=-0.163,P>0.05)不存在相关性。结论AS患者血清Cy PA明显上调,并与ESR、CRP及ASDAS密切相关,提示Cy PA可能在AS发病及炎症活动过程中起重要作用。
Objective To investigate the relationship between serum Cyclophilin A (Cy PA) and clinical disease activity in patients with ankylosing spondylitis (AS). Methods Totally 30 active AS patients and 30 healthy volunteers (HV group) were enrolled in the Second People’s Hospital of Guangdong Province and the Third Affiliated Hospital of Sun Yat-sen University from October 2010 to March 2011. ELISA was used to detect two The serum levels of Cy PA were compared between the two groups. The serum levels of Cy PA in AS patients were compared with those of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), BASFI and BASDAI The newly generated AS Disease Activity Index (ASDAS) was analyzed by Pearson correlation. Results The level of serum Cy PA in AS group was significantly higher than that in HV group [(34.6 ± 11.0) μg / m L vs (22.7 ± 8.0) μg / m L, P <0.05] There was a positive correlation between ASDAS-CRP (r = 0.436, P <0.05), CRP (r = 0.463, But no correlation with BASDAI (r = -0.163, P> 0.05). Conclusions The serum levels of Cy-PA in patients with AS are significantly up-regulated and closely related to ESR, CRP and ASDAS, suggesting that Cy PA may play an important role in the pathogenesis and inflammatory process of AS.