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目的:观察甲状腺功能异常对稳定性心绞痛患者发生心房颤动(房颤)的影响。方法:纳入稳定性心绞痛患者617例为研究对象,根据患者血浆中促甲状腺激素(TSH)水平分成TSH<0.55 m IU·L-1组、0.55~4.78 m IU·L-1组、>4.78 m IU·L-1组。比较3组实验室检查的结果及各组房颤发生率。结果:617例稳定性心绞痛患者中,48例诊断为阵发性或持续性房颤,发生率为7.8%。房颤发生率TSH 0.55~4.78 m IU·L-1组最低,为6.3%(34/543);TSH>4.78 m IU·L-1组最高,为19.6%(9/46),TSH<0.55 m IU·L-1组为17.9%(5/28),3组之间差异有统计学意义(P=0.001)。相关性分析结果显示,甲状腺功能异常与稳定性心绞痛患者发生房颤存在相关性。结论:甲状腺功能异常与稳定性心绞痛患者房颤的发生相关,对合并甲状腺功能异常的稳定性心绞痛患者应警惕和预防房颤的发生。
Objective: To observe the effect of abnormal thyroid function on atrial fibrillation (AF) in patients with stable angina. Methods: A total of 617 patients with stable angina pectoris were enrolled in this study. The levels of TSH <0.55 m IU · L-1, 0.55 ~ 4.78 m IU · L-1 and> 4.78 m IU · L-1 group. The results of three groups of laboratory tests and the incidence of atrial fibrillation in each group were compared. Results: Of the 617 patients with stable angina pectoris, 48 were diagnosed as paroxysmal or persistent atrial fibrillation with a prevalence of 7.8%. The lowest incidence of atrial fibrillation (TSH> 4.78 m IU · L-1) was TSH <0.55 (19.6%, TSH <0.55 m IU · L-1 group was 17.9% (5/28), the difference between the three groups was statistically significant (P = 0.001). Correlation analysis showed that there was a correlation between thyroid dysfunction and atrial fibrillation in patients with stable angina. Conclusion: Thyroid dysfunction is associated with the occurrence of atrial fibrillation in patients with stable angina and should be vigilant and prevent atrial fibrillation in patients with stable angina pectoris.